Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR3
نویسندگان
چکیده
Division of Cellular Therapy, Advanced Clinical Research Center, The institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan National Institute of Vegetable and Tea Science, National Agriculture Research Organization, 2769 Kanaya, Shizuoka 428-8501, Japan R&D System, Inc. 614 Mckinley Place N.E. Minneapolis, MN 55413 Devision of Immune Cell Biology, National Institute for Medical Research, London, United Kingdom Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo, Sendai 980-8575, Japan Running title: Functional analysis of LMIR4 Address correspondence to: Toshio Kitamura, Division of Cellular Therapy, Advanced Clinical Research Center, The institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Tel. +81-3-5449-5759; Fax. +81-3-5449-5428; E-Mail: [email protected]
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An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells.
Leukocyte mono-Ig-like receptor 3 (LMIR3) is an inhibitory receptor mainly expressed in myeloid cells. Coengagement of Fc epsilonRI and LMIR3 impaired cytokine production in bone marrow-derived mast cells (BMMCs) induced by Fc epsilonRI crosslinking alone. Mouse LMIR3 possesses five cytoplasmic tyrosine residues (Y241, Y276, Y289, Y303, Y325), among which Y241 and Y289 (Y241/289) or Y325 fit th...
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